toshiba a60 wont start up?

ok a friend of mine gave me his lap top to look at coz some thing has gone wrong, his mother in law used a usb flash drive in it and it went from there, now when u start it up you get the message windows could not start because the following file is missing or corrupt system32driversntfs.sys says you can attempt to repair this file by starting windows set up using the orignal set up cd rom,,, which he aint got , i tryed using a different windows disc to boot from i had no luck also it has come up system32driversisapnp.sys.
how can i fix this ?
can i wipe the laptop and restart with a different windows?
or does this need pulling apart and building with new parts.
any help would be very greatful