With a cautious tone, yes, it should be safe. A Vaillant without pressure will generally throw up a F.22 or F.25 fault (lack of water), so it would be fair to suggest, some pressure exists in the system.
However, you will need to get the guage cleared/renewed asap just to make sure.
This would involve removing the pump, as the connection for the guage is behind it
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February 2015